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PD-161570 - CAS# 192705-80-9 0114 2008 Oct 15

SKU: 11330351797

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Description

2008 Oct 15

PD-161570 - CAS# 192705-80-9 0114 2008 Oct 15PD 161570, CAS No. 192705 80 9, is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5 and 100 fold greater selectivity toward the FGF 1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3. 7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF 1 receptor in both human

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