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a PKC substrate
LCB 2853 shows an ED50 lower than 1 mg/kg i
CAS Number: 1433953-83-3
Formula: C16H34N2O8
Pre-treatment with 2 and 6 μM Xanthorrhizol reduces tumor multiplicity to 6
BDA-366 Size:Contact [email protected] for quotation a PKC substrateBDA 366 is a selective antagonist of BCL2 BH4 domain with Ki value of 3. 3 nM . BCL2 is an important anti apoptotic protein. BCL2 homology 4 (BH4) domain is required for its antiapoptotic function, thus acts as a promising anticancer target . BDA 366 is a selective BCL2 inhibitor. BDA 366 induced conformational change of BCL2 that exposed the BH3 domain, resulting in abrogation of its prosurvival function and conversion of BCL2 to a prodeath protein.
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