TG101348 (SAR302503) - JAK2 and BRD4 Dual Inhibitor. CAS# 936091-26-8 size:2 mg solid Chemical Name: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3

Chemical Name: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3

and FLT3-ITD/F691L in cellular assays

Minegishi Y

Formula: C15H22N2O4

in all U0126 experiments

TG101348 (SAR302503) - JAK2 and BRD4 Dual Inhibitor. CAS# 936091-26-8 size:2 mg solid Chemical Name: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3TG101348, CAS No. 936091 26 8, is a potent, specific and orally bioavailable inhibitor of JAK2 (IC50 ~3 nM) and BRD4 (IC50 ~164 nM). It is 35 and 334 fold more selective for JAK2 versus JAK1 and JAK3. It also significantly inhibits JAK2 V617F, Flt3, and Ret with IC50 of 3 nM, 15 nM, and 48 nM, respectively. TG101348 induces apoptosis in both HEL and Ba F3 JAK2V617F cells, but not in normal human dermal fibroblasts at concentrations up to 10 uM, and